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status of HGF, adiponectin levels and histopathology of liver in NASH.

Journal of the association of physicians of india • november 2013 • VOL . 61 15
Abstract
Objectives: Hepatocyte growth factor (HGF) and Adiponectin are adipokines. Serum HGF and adiponectin
levels are strongly associated with liver disease, obesity, insulin resistance and metabolic syndrome (MS).
Non alcoholic steatohepatitis (NASH) is the hepatic component of metabolic syndrome. Our aim was to
elucidate the status of HGF, adiponectin levels and histopathology of liver in NASH.
Methods: This study was conducted among 50 subjects (25 patients and 25 controls) age and sex matched
attending OPD. Patients were randomly selected for the study and after explaining in detail design of the
study, written consent was taken. Institutional ethical approval was also taken. The only diagnostic method
for NASH is liver biopsy (after exclusion of other causes based upon clinical examination and laboratory
investigations) and pathological grading and staging was done according to Brunt classification. Diagnosis
of patients was done on the basis of liver biopsy and fasting HGF and adiponectin were performed with
commercially available ELISA kits (quantikine HGF and adiponectin ELISA kits).
Results: Mean serum HGF in patient and control groups were 2.33 ± 0.66 pg/ml and 0.56 ± 0.21 pg/ml
respectively (p < 0.001). Mean serum adiponectin in patient and control groups were 6.93 ± 1.50 ng/ml
and 14.54 ± 3.58 ng/ml respectively (p < 0.001). Multiple regression analysis revealed that statistically
significant difference was found (p < .001) when comparing mean brunt grade and brunt stage (hepatic
histopathology) with fasting serum adiponectin and HGF
Conclusion: Fasting serum HGF was significantly high and fasting serum adiponectin was significantly low
in patients of various grades of hepatic histopathology in NASH. Various parameters of MS were significantly
correlated with various stages of hepatic histopathology, as well as decreased serum adiponectin and
increased fasting serum HGF.
*Professor, **Sr. Resident,
***Associate Professor, ****Sr.
Registrar, †Assistant Professor,
Diabetes Care and Research
Centre, S.P. Medical College,
Bikaner
Received: 14.02.2012;
Revised: 15.06.2012;
Re-revised: 10.07.2012;
Accepted: 12.07.2012
Introduction
NASH is considered to be the hepatic
component of metabolic syndrome.
All of the predictors of progression of
fibrosis in patients with NASH such
as age (> 45 year old), obesity ([body
mass index] BMI ≥ 30 kg/m2), fibrosis or
cirrhosis (AST/ALT > 1), and diabetes,
are associated with increased Insulin
Resistance (IR).1 As a result, even though
non-alcoholic steatohepatitis (NASH)
is a multifactorial disease, IR seems to
be the main factor that is responsible
Hepatocyte Growth Factor, Adiponectin and
Hepatic Histopathology in Non-Alcoholic
Steatohepatitis
RP Agrawal*, Vikas Sheroan**, Vipin Ola**, AA Sulemani***, Neetu Singh***,
P Sirohi***, Sunil Gothwal****, Jai Kumar

homeopathy for all Volume 14 date 15 th April 2013 page no. 56

Songs from Rajasthan - Kesariya Balam

Homoeopathy & Bikaner: Stretch Marks

Homoeopathy & Bikaner: Stretch Marks: Most of us pick up stretch marks at some point in our lives, whether it be from growing, rapid weight gain or loss, puberty, or carrying ...

Stretch Marks

Most of us pick up stretch marks at some point in our lives, whether it be from growing, rapid weight gain or loss, puberty, or carrying a child.

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​Everybody gets stretch marks (also known as striae). While not harmful, stretch marks are not very cosmetically appealing. Whether yours are from puberty, pregnancy, weight loss/gain or simply a change in shape, they can be fixed.

Stretch marks are usually caused by relatively rapid pulling or stretching of the skin. This usually happens over several weeks or months, however stretch marks can appear rapidly and without warning.

Pregnant women often experience the most severe cases, however, bodybuilders and even normal teens can get stretch marks.

Typical symptoms of stretch marks are red or purple marks in a linear pattern, usually on the hips, upper thighs, arms, breasts or stomach. Although it is not at all uncommon to have stretch marks in other areas. Stretch marks occur as a result of tearing of the dermis, which is the middle, support layer of the skin.

It is very difficult to prevent stretch marks, as they can appear without warning and quite often follow rapid changes in body size. However, it can be possible to prepare for stretch marks during pregnancy by beginning an early procedure of skin care.

There is no immediate, surefire way to completely eradicate stretch marks. However, there are several options which can help you reduce and eventually remove your stretch marks. The effectiveness of these treatments depends on your age, skin type, ethnicity, diet and body shape.

smoking cessation

Smoking cessation refers to quitting smoking. Quitting smoking is not easy, but there are things you can do to increase your chances of success.

Why it is hard to quit smoking? An addictive drug called Nicotine is present in all tobacco products. Smoking tobacco, and other forms of tobacco use, creates an addiction to nicotine. Addictive drugs like nicotine cause changes in the brain that create good feelings when used and unpleasant feelings (withdrawal symptoms) when discontinued. Nicotine addiction is one of the hardest addictions to break.

Getting Ready to Quit Smoking: 
• Determine a quit date.
• Choose a method for quitting.
• Decide with your health care provider if you need medicines to help you quit.

Tips for Quitting Smoking: 
• Eat a balanced diet, stay well hydrated and well-rested.
• Get a little exercise every
• Select healthy alternatives to reduce urges.
• Ask for support from family and friends.
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Tools for Quitting Smoking: 
1. Nicotine Replacement Therapies
2. Common drug therapies for nicotine withdrawal
3. Counseling for smoking cessation